Cryptococcal meningitis following fludarabine treatment for chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Treatment of fludarabine-refractory chronic lymphocytic leukemia.
The development of resistance to purine analogs defines a poor-risk subset of patients with chronic lymphocytic leukemia (CLL). Although in recent years chemoimmunotherapeutic combinations such as fludarabine, cyclophosphamide, and rituximab have induced response rates of 95% in previously untreated patients and increased the rates of failure-free survival, CLL remains incurable for many patien...
متن کاملFatal Cryptococcal Meningitis in a Patient with Chronic Lymphocytic Leukemia
Patients with chronic lymphocytic leukemia (CLL) are susceptible to infections, especially opportunistic infections. We have described a patient with CLL who had cryptococcal meningitis. Despite lack of previous immunosuppressive treatment history, the patient experienced serious and fatal fungal infection. Physicians should be alert for a diagnosis of cryptococcal meningitis in patient with CL...
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Fludarabine (FAMP) is the most effective and most extensively studied purine analog in indolent B-cell malignancies. Its use is indicated for first-and second-line treatment of B-cell chronic lymphocytic leukemia (B-CLL). FAMP as a single agent has produced superior response rates and progression-free survival than standard therapy with chlorambucil and alkylator-based regimen. Efficacy of FAMP...
متن کاملProgressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient.
UNLABELLED Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70-90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may occur, if the immune function is compromised. AIM To present a PML case in a CLL patie...
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ژورنال
عنوان ژورنال: European Journal of Clinical Microbiology & Infectious Diseases
سال: 1995
ISSN: 0934-9723,1435-4373
DOI: 10.1007/bf01691005